Drug manufacturers have tried to copy (genetically engineer) and market several of the individual components of colostrum, most notably interferon, gamma globulin, growth hormone, IgF-1 and protease inhibitors. Some of the following colostrum components may very well be next on the list of major breakthroughs by the pharmaceutical/nutraceutical industry: Immunoglobulins (A, D, E, G and M) – the most abundant of the immune factors found in colostrum; IgG neutralizes toxins and microbes in the lymph and circulatory system; IgM destroys bacteria while IgE and IgD are highly antiviral.
Growth Factors Found in Colostrum:
- Growth hormone (GH)
- Insulin-like growth factor-I and II (IGF-1 and IGF-II)
- Epithelial growth factor (EgF)
- Fibroblast growth factor (FgF)
- Platelet-derived growth factor (PDGF)
- Transforming growth factors A & B (TGF A and B).
The body’s growth factors are capable of increasing T-cell production, accelerating healing, balancing blood glucose, reducing insulin need, increasing growth and repair of vital tissues while metabolizing fat for fuel. Medical studies have shown the vital growth factors IgF-1, TgF A & B and nucleotides from bovine colostrum to be identical to human in composition and helps provide the raw materials to repair vital DNA and RNA in the bodies cells. Further, by stimulating DNA formation it has been shown that they can help stimulate normal cell and tissue growth, regeneration and accelerated repair of aged or injured muscle, skin collagen, bone, cartilage, nerve tissues, heart muscle and new blood vessels for collateral coronary circulation. These growth factors facilitate the healing of tissues damaged by ulcers, trauma, burns, surgery or inflammatory disease. ..”Transforming Growth Factors A & B (TGF A & B) in bovine Colostrum were involved in normal cellular activities such as cell proliferation, and tissue repair. Also reported it promoted the synthesis and repair of DNA – the master code of the cell.” …July 1992 New England Journal of Medicine.
Colostrum provides a good source of IgF-1 as a complementary therapy for successful weight loss and building of lean muscle. IgF-1 is required by the body to metabolize fat for energy through the Krebs cycle but with aging, less IgF-1 is produced in the body. It helps stimulate the body to burn fat for fuel instead of the body’s own muscle tissue in times of diet and fasting. “High age is associated with reduced levels of growth hormones: GH and IgF-1. Induction of GH and IgF-1 increase body weight through muscle growth of aged subjects” …Drs. Ullman, Sommerland & Skottner, Dept. of Pathology and Pharmacology, Univ. of Gothenburg, Sahlgren Hospital & HabiVitrum AB, Stockholm, Sweden
Human trials in 1990 reported that IgF-1 stimulates glucose utilization. It can help balance blood sugars (non insulin diabetics and hypoglycemia). Inadequate levels of IgF-1 are associated with an increased incidence of Type II diabetes and difficulty in losing weight despite a proper nutritional intake and adequate exercise.
Additionally, IgF-1 and GH in colostrum normalizes LDL-cholesterol while increasing HDL-cholesterol concentrations (the good cholesterol).
Genetically engineered versions of IGF-1 and GH are now marketed but they are found in high concentrations in colostrum. Biotechnology companies are currently selling IgF-1 for as much as $800 per 50 cc vial. GH is also very expensive. Even less expensive products marketed as growth hormone releasers (designed to help the body to manufacture their own HGH) are markedly more expensive than Colostrum. None of these expensive products contain any of the vast array of immune factors.
Immune Factors Found in Colostrum:
- Immunoglobulins (A,D,E,G &M;)
- Gamma Globulin
- Cytokines: Interleukins 1,6,10;Interferon G;lymphokines
- Proline-Rich-Polypeptides (PRP)
- Protease Inhibitors
- Trypsin Inhibitors
- Lactobacillus Bifidus Acidophilus
- Oligo Polysaccharides
- Orotic Acid
- Secretory IgA
- IgA specific helper
- B Lactoglobulin
- Alpha 1-Antitripsin
- Alpha 1-Fetoprotein
- Alpha 2-Macroglobulin
- Alpha 2- AP Glycoprotein
- C3 & C4 Orosomucoids
- Xanthine Oxidase
- Vitamins A, B12, E
Colostrum and breast milk (from cows and humans) stimulates the newborns immune system; as yet, unidentified proteins speed the maturation of cultured B Lymphocytes (type of white blood cell) and primes them for production of antibodies… “Clinical research by Dr. David Tyrell, in England, in 1980, revealed that a high percentage of the antibodies and immunoglobulins present in colostrum are believed not to be absorbed but remain in the intestinal tract where they attack disease causing organisms before they penetrate the body and cause disease. The remainder are believed to be absorbed and distributed to assist in our internal defense processes. It is this combination of action that is believed to make colostrum so unique and effective as an oral supplement.” …
“Studies with human volunteers found that the preservation of the biological activity of IgG (Immunoglobulin), in the digestive secretions of adults receiving bovine colostrum orally, indicates passive enteral (intestinal) immunization for the prevention and treatment of acute intestinal diseases… Dr. L.B. Khazenson; Microbial & Epidemial Immunobiology.
Antibodies: Colostrum has been shown to contain specific antibodies that may help our body in its fight against specific diseases such as pneumonia, RVS, dysentery, candida, flu, and numerous other illnesses Lactoferrin: an antiviral, anti-bacterial, anti-inflammatory, iron-binding protein with therapeutic effects in cancer, HIV, Cytomegalovirus, herpes , Chronic fatigue Syndrome, Candida albicans and other infections.
Lactoferrin: helps deprive bacteria of the iron they require to reproduce and releases iron into the red blood cells enhancing oxygenation of tissues. Lactoferrin modulates cytokine release and its receptors have been found on most immune cells including lymphocytes, monocytes, macrophages and platelets… “Concentration of Lactoferrin and Transferrin in bovine colostrum found necessary to transport iron into blood. Highest concentrations of both substances were found in the first milking after birth” …Drs. Sanchez, et al, Biological Chemistry
Proline-Rich Polypeptide (PRP): a hormone that regulates the thymus gland (bodies central command for the immune system), stimulating an under active immune system or down-regulating an overactive immune system as seen in autoimmune disease (MS, rheumatoid arthritis, lupus, scleroderma, chronic fatigue syndrome, allergies, etc.). It has been demonstrated to improve or eliminate symptomatology of both allergies and autoimmune diseases. PRP inhibits the overproduction of lymphocytes and T-cells and reduces the major symptoms of allergies and autoimmune disease: pain, swelling and inflammation… “PRP, in bovine colostrum, has the same ability to regulate activity of the immune system as hormones of the Thymus gland. It activates an underactive immune system, helping it move into action against disease-causing organisms. PRP also suppresses an overactive immune system, such as is often seen in the autoimmune diseases. PRP is highly anti-inflammatory and also appears to act on T-cell precursors to produce helper T-cells and suppresser T-cells” …Drs. Staroscik, et. al., Molecular Immunology.
… “PRP turns white blood cells into functionally active T cells. Results were shown in treatment of auto-immune disorders and cancer. An important Immune modulator stimulates an underactive immune system and tones down an overactive one”…Drs. Janusz & Lisowski; Archives of Immunology
Glycoproteins: (Protease inhibitors) A digestive factor that has been shown to help immune and growth factors survive the passage through the highly acidic digestive system.
Lactalbumin: Research indicates tremendous possibilities that lactalbumins can be highly effective against numerous forms of cancer and viruses. Colostrum Lactalbumin has been found to be able to cause the selective death (paposes) of cancer cells, leaving the surrounding non-cancerous tissues unaffected. Lactobacillus Bifidus Acidophilus: Friendly flora which is necessary for the digestion of food and in the reduction of the growth of harmful bacterial in the digestive system. Shown to effectively combat candida albicans.
Cytokine’s: Interlukin 1 & 6, Interferon Y and Lymphokines: Shown to stimulate the lymph glands and are thought to be highly effective antiviral immune substance. Interleukins that regulate the duration and intensity of the immune response, are responsible for cell to cell communication, boost T-cell activity and the production of immunoglobulins. Interleukin-10 is strongly anti-inflammatory, especially in arthritic joints.
The benefits of cytokines in the treatment of cancer was first popularized by the 1985 Steven Rosenberg Book, Quiet Strides in the War on Cancer. Since that time, the same cytokines found in colostrum (Interleukins 1, 6, 10, Interferon G and Lymphokines) have been the single most researched protocols in scientific research for the cure for cancer.
Vitamins and Minerals: Colostrum is not a supplement… it is the whole food for the newborn… its combination of vitamins and minerals are naturally occurring and in perfect combination. Vitamins – A, B12 and E are found in small amounts while traces of all others are also present in colostrum.
Sulfur: A mineral with multiple uses in metabolism and as part of many structural body proteins.
Leukocytes: Stimulate the production of interferon, which slows viral reproduction, and penetration of cell walls.
Enzymes: Lactoperoxidase-thiocyanate, peroxidase and xanthine oxidase oxidize bacteria through their ability to release hydrogen peroxide.
Lysozyme: A hydrolyzing agent and immune system booster capable of destroying bacteria and viruses on contact.
Trypsin Inhibitors and Protease Inhibitors: Prevent the destruction of immune and growth factors in colostrum from being broken down in the GI tract; they also prevent H. pylori from attaching to the walls of the stomach and can have a beneficial role in the treatment of peptic ulcers.
Lymphokines: Hormone-like peptides produced by activated lymphocytes which mediate the immune response.
Oligo Polysaccharides and Glycoconjugates: attract and bind to pathogens (Strep., E. Coli ), Salmonella, Cryptosporidia, Giardia, Entamoeba, Shigella, Clostridium Difficile Toxins A & B and Cholera) preventing them from attaching or entering the mucous membranes.
Orotic Acid: Stops the formation of pyrimidine nucleotides and prevents hemolytic anemia.